Asymmetric Synthesis of .ALPHA.-Substituted Serines.
نویسندگان
چکیده
منابع مشابه
Chemoenzymatic Synthesis of -Substituted Serines via Enantiodivergent Transformation
A series of (R)-N-Cbz-2-alkyl-2-amino-3-hydroxypropyl acetates was prepared by enzymatic acetylation of NCbz-2-alkyl-2-aminopropane-1,3-diols with immobilized lipoprotein lipase from Pseudomonas sp. in up to 98% enantiomeric excess (ee). Enantiodivergent oxidation of (R)-N-Cbz-2-alkyl-2-amino-3-hydroxypropyl acetates readily furnished (R)and (S)-substituted serines ( -benzylserines and -methyls...
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 2000
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.58.756